The presence of sNS1:HDL complexes as a predominant population of sNS1 in our in vitro infection model corroborates with a previous report of an interaction between insect-derived recombinant NS1 and the classical HDL/ApoA1-binding receptor known as SR-BI (Alcalá et al., 2022), which is primarily expressed on hepatocytes (Acton et al., 1996). Here, APOA1 is linked to infection.