Finally, clinical tissue specimens and <i>in vitro</i> function assays were conducted to validate the expressions and effects of CUL2 on the biological functions in hepatocellular carcinoma (HCC) cells.<h4>Results</h4>While there are variations in CUL2 expression across different organs and cell types, it is notably upregulated in a majority of tumor tissues. Here, CUL2 is linked to neoplasm.