Interestingly, the silencing of the c/ebp gene, which encodes the transcription factor C/EBP1 that binds to the IL-6 gene promoter and positively controls its expression in synoviocytes, led to the downregulation of IL-6 and ameliorated mesangial cell proliferation and extracellular matrix expansion in rats with Thy1.1 nephropathy [60]. This evidence concerns the gene HERC5 and kidney disorder.