Notably, the presence of hepatitis C (OR = 4.0; CI: 1.2–18.3; p = 0.041), direct bilirubin ≥ 0.20 mg/dL (OR = 24.0; 95% CI: 7.5–106.8; p < 0.001), indirect bilirubin ≥ 0.78 mg/dL (OR = 8.3; 95% CI: 3.2–23.0; p < 0.001), and GGT ≥ 82.5 IU/L (OR = 5.7; 95% CI: 2.2–15.7; p < 0.001), as well as low levels of albumin of ≤3.7 g/dL (OR = 21.2; 95% CI: 4.2–386.7; p = 0.003) and CD4 counts ≤ 191.5 cells/mm3 (OR = 5.8; 95% CI: 2.2–16.3; p < 0.001), were identified as significant risk factors for advanced fibrosis in HIV patients. This evidence concerns the gene CD4 and hepatitis C virus infection.