In this respect, conflicting reports exist about COVID-19 severity and mortality in people living with HIV-1 (PLWH), ranging from increased, especially in patients with lower CD4+ T cell counts with or without uncontrolled HIV-1 replication, to reduced, due to a possible anti-SARS-CoV-2 activity of antiretroviral drugs [152,153,154,155,156]. This evidence concerns the gene CD4 and COVID-19.