A study of 667 canine tumour specimens found that apart from UC and PC, the BRAF p.V595E mutation was only present in a few tumour types and at low frequency, specifically pulmonary carcinoma (n = 1/18), oral squamous cell carcinoma (n = 2/18), melanoma (n = 3/54), melanocytoma (n = 3/18), glioma (n = 2/13) and peripheral nerve sheath tumour (n = 2/9), but no haematopoietic tumours (n = 245) or sarcomas (n = 160) [30]. This evidence concerns the gene BRAF and pachyonychia congenita.