One study found that survival of the dogs with BRAF p.V595E urinary bladder tumours was significantly dependent upon the treatment regimen, and those receiving adjuvant metronomic chlorambucil after mitoxantrone showed greater than double the MST compared to patients receiving mitoxantrone alone (588 versus 216 days, p = 0.030). Here, BRAF is linked to urinary bladder neoplasm.