ACOT1 and Hepatic steatosis: Proteins involved in hepatic steatosis progression are predominantly upregulated, with a few proteins downregulated in the PFOS SD versus VEH SD comparison, as visualized in Figure 7C. The top upregulated proteins include: Ehhadh, Cyp4a14, Acot1, Acox1, and Succinate-hydroxymethylglutarate CoA-transferase (Sugct).