Apparent mineralocorticoid excess (AME) is a rare autosomal recessive disorder caused by a deficiency in the 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2), which physiologically converts cortisol to cortisone, thus protecting mineralocorticoid receptor (MR) activation by cortisol [45,46,47,48]. Here, NR3C2 is linked to Increased circulating aldosterone concentration.