Glucocorticoid remediable aldosteronism (GRA) or familial hyperaldosteronism I (FH I) is caused by a chimeric gene in which the ACTH-responsive 5′-promoter of the 11Beta-hydroxylase gene is fused to coding sequences of the aldosterone synthase gene, resulting in a hybrid protein that stimulates aldosterone production independently of renin [42]. Here, REN is linked to glucocorticoid-remediable aldosteronism.