Regarding blood IL-27 levels and clinical outcome, Eric et al. [34] studied the association of serum IL-27 levels with in-hospital mortality in 151 critically ill patients with peritonitis, pancreatitis, or trauma who were admitted to the intensive care units, and they reported that IL-27 levels on admission were significantly higher in patients who died during hospital than in those who survived. Here, IL27 is linked to pancreatitis.