Genes like Akt kinase (AKT), Phosphoinositide 3-kinase (PI3K), Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2), p38 mitogen activated protein kinase (P38 MAPK) and Protein kinase C (PKC) are known cancer-related genes, and some of them are also involved in periodontitis [158]. This evidence concerns the gene MAPK3 and periodontitis.