Even if the etiopathogenetic of euDKA induced by an SGLT2-i is not yet clear, an important role is played by a long list of precipitating factors, such as concurrent pathologies, infection, sepsis, dehydration, acute cardio-vascular events, a reduction in caloric and/or fluid intake, low-carbohydrate diet, a significant reduction in the daily insulin dose in insulin-treated patients and surgery. The gene discussed is SLC5A2; the disease is infection.