The proportional reporting ratio (PRR) of DKA in DM patients taking an SGLT2-i vs. those not taking it was 7.9 (confidence interval [95% CI] 7.5–8.4), and it was higher for T1DM (PRR 57.3; 95% CI 49.2–66.6). This evidence concerns the gene SLC5A2 and diabetes mellitus.