The increased amplification of c-Myc in Glu-deprived SF188 glioma cells induces the overexpression of glutamate dehydrogenase, which enables glioma cells to use glutamine to survive, increasing α-KG levels and ultimately OA, citrate, pyruvate, and Ac-CoA through the TCA [314]. This evidence concerns the gene MYC and central nervous system cancer.