Also, evofosfamide decreases the tumor volume and weight in murine glioma xenograft models, and higher levels of HIF1α, PDHK1, G6P, F6P, DHAP, 3PG, PEP, Pyr, and lactate in tumor tissue induce an increase in the overall survival in the treated animals in relation to the control group [241]. The gene discussed is PDK1; the disease is central nervous system cancer.