However, integrating and deepening our knowledge of the cellular and molecular processes induced by p53, HIF1, and c-Myc, as well as the crosstalk between them and the signaling pathway that regulates their crosstalk with components of the microenvironmental including cells of the immune system, are essential for understanding glioblastoma and devising novel therapeutic approaches. This evidence concerns the gene TP53 and glioblastoma.