Fenofibrate administration inhibited colon cancer cell proliferation and significantly decreased tumor volume in tumor xenograft experiments using HCT116 cells, weakening DNMT1 activity and restoring CDKN2A expression.Fenofibrate had anticancer effects on cervical cancer HeLa cells via inducing caspase-dependent apoptosis and cell cycle arrest. (NCT01965834;NCT00357500;NCT01356290). Here, CDKN2A is linked to colonic neoplasm.