Resveratrol modulates signaling pathways such as Notch, JAK/STAT, and NF-κB in cancer cells.Resveratrol increases the TMZ cytotoxicity in glioma cells.Resveratrol plus iododeoxyuridine enhanced the radiosensitization of U87MG spheroids. (NCT00098969; NCT00433576; NCT01476592). Here, SOAT1 is linked to central nervous system cancer.