PX-478 (S-2-amino-3-[4′-N,N,-bis(chloroethyl)amino]phenyl propionic acid N-oxide dihydrochloride) is an orally bioavailable agent that suppresses constitutive and hypoxia-induced HIF1α in cancer cell lines at multiple levels by selectively inhibiting HIF1α translation, reducing its mRNA levels, and inhibiting its deubiquitination [345]. The gene discussed is HIF1A; the disease is cancer.