Studies carried out by many researchers conclude that the metabolic reprogramming in glioblastoma results from genetic alterations, in which the signaling pathways RAS/RAF/MERK/ERK and PI3K/AKT/mTOR regulate glucose, nucleotide, protein, and lipid metabolism to support glioma cell proliferation, growth, migration, and invasion. This evidence concerns the gene AKT1 and central nervous system cancer.