Co-treatment with PRIMA-1MET and panobinostat (a HDAC inhibitor), 3-deazaneplanocin (an EZH2 histone methyl transferase inhibitor), or TMZ act synergistically, suppressing the capacity for colony formation on plate and agar, promoting apoptosis in mut- or wt-p53 GBM cells [339]. The gene discussed is TP53; the disease is glioblastoma.