p53 also contributes to glioma cell survival by upregulating the transcription of enzymes involved in mevalonate metabolism, such as 3′-hydroxy-3′-methylglutaryl-CoA reductase, MVK, FDPS, FDFT, geranylgeranyl transferase 1α, and LDL receptor, independently from SREBP1 and SREBP2, promoting cholesterol de novo synthesis [173]. This evidence concerns the gene HMGCR and central nervous system cancer.