IDH1 and central nervous system cancer: JQ-1, a pan-inhibitor of bromodomain and extra-terminal (BET) proteins such as the epigenetic readers BRD2, BRD3, and BRD4, exerts a cytotoxic effect on BT142 glioma cells with mutated IDH, by inhibiting BRD4 and c-Myc downregulation [404].