Similarly, the activation of the complex I subunit NADH dehydrogenase (ubiquinone) 1α subcomplex and subunit 10 of complex III (INDUFA10) of the ETC decreases reactive oxygen species (ROS) generation and p53 activation, inhibiting the glycolytic switch and GLUT1,-3, PDHK1, and LDHA expression, thus reducing cell proliferation in neural stem cells and tumor formation upon transplantation into mouse brain [149] (Figure 3). This evidence concerns the gene PDK1 and neoplasm.