Propofol enhances the sensitivity of TMZ-resistant GBM in vivo, decreases tumor growth, and enhances the effect of TMZ on macrophage infiltration, inflammation, and apoptosis.Propofol (5 or 10 μg/mL) activated miR-410-3p expression and inhibited TGFBR2 expression in glioma cells, generating inhibition of glioma cell development. (NCT04962672; NCT05273827). This evidence concerns the gene TGFBR2 and central nervous system cancer.