p53 also blocks lactate production and inhibits lactate transport into and out of tumor cells by negatively regulating lactate dehydrogenase A (LDHA) and reducing the stability of the monocarboxylate transporter 1 (MCT1) mRNA [88] or inducing the degradation of HIF1α, a transcriptional regulator of LDHA and MCT1 [89,90]. This evidence concerns the gene LDHA and neoplasm.