Also, evofosfamide decreases the tumor volume and weight in murine glioma xenograft models, and higher levels of HIF1α, PDHK1, G6P, F6P, DHAP, 3PG, PEP, Pyr, and lactate in tumor tissue induce an increase in the overall survival in the treated animals in relation to the control group [241]. Here, HIF1A is linked to central nervous system cancer.