In addition, the activation of HIF1 under hypoxia conditions in G06A, SDT3G, and J3TBg canine glioma cell lines induces the overexpression of HIF1α, GLUT1, and PDHK proteins, lactate levels, and higher production in the ATP levels via glycolysis that generate at mitochondrial levels, which significantly increases the cell viability from glioma cells. Here, HIF1A is linked to central nervous system cancer.