The overexpression of mutated IDH1 in U87 and U251 glioma cells decreased cell proliferation, migration, and invasion whilst promoting apoptosis and improving chemosensitivity to TMZ by increasing the expression of FAT atypical cadherin 1; this protein promotes ROS generation by decreasing NADPH+ levels, the activity of superoxide dismutase 2 (SOD2), and thr glutamate-cysteine ligase catalytic subunit, resulting in the upregulation of HIF1α [257]. The gene discussed is HIF1A; the disease is central nervous system cancer.