MYC and central nervous system cancer: MYCi975, a small molecule, binds directly to the HLH domain of c-Myc, decreasing its transcriptional activity [414], blocking the formation of the mediator subunit 1 (MAD)/c-Myc complex, and inhibiting the transcription of TMEM44-AS1, an lncRNA, thereby reducing cell viability and the ability to form colonies in glioma cells.