HIF1A and central nervous system cancer: Jing-Huei et al. reported that Nodal, a TGFβ family member, promotes a shift in Glu metabolism by inducing HIF1 transcription, which increases GLUT1, HX2, and PDHK expression, as well as the phosphorylation (inactivation) of PDH, favoring Glu uptake, increasing lactate levels, and decreasing mitochondrial OXPHOS in human GBM8401 and U87 MG glioma cells under normoxic conditions [240].