CD274 and glioblastoma: Li et al. showed that silencing karyopherin α2 (KPNA2) in U87 and U251 GBM human cells decreases cell proliferation and invasiveness by downregulating the expression and translation of GLUT1, MCT1, PFK2, PKM1, programmed death-ligand 1 (PDL1), GLS, and SLCA5 mRNA and decreasing 2-deoxyglucose uptake and lactate production; meanwhile, the OXPHOS rate was moderately inhibited [310].