MDM2 and central nervous system cancer: Weinmann et al. demonstrated the anti-proliferative effect of P53R3 on mut-p53 LN-308 sublines via cell cycle arrest; in mut-p53 T98G glioma cells, P53R3 induces the expression of genes positively modulated by p53, including mdm2, p21, growth arrest and DNA damage 45 (GADD45), Bax, Fas death ligand (CD95L), Puma, p53-inducible gene 3,-6 (PIG3-6), and death receptor (DR5).