In summary, the LOS (with an appropriate intracellular dose of ROS) exhibited consistent enhancement in gene transcription related to the EMP, the PPP, the TCA cycle, the DAP, and ε-PL accumulation, whereas excessive ROS within the HOS led to a metabolic disorder characterized by both the upregulation and downregulation of gene transcription involved in the EMP, PPP, and TCA cycle. This evidence concerns the gene MAEA and metabolic disease.