In gastric cancer, miR-17-5p, the prominent member of the miR-17-92 cluster, regulates stem cell characteristics to promote the growth of gastric cancer cells via specifically targeting runt-related transcription factor 3 (RUNX3) gene, while the knockdown of miR-17-5p results in a significant reduction of proliferation, invasion, and metastasis via targeting phosphatase and tensin homolog deleted on chromosome 10 (PTEN) [32,33,34]. Here, PTEN is linked to gastric cancer.