Regarding the relationship between CDX2 expression and histological subtypes of CRC, the study conducted by Asgari-Karchekani et al. noted that mucinous adenocarcinoma typically exhibits negative or reduced CDX2 expression, in contrast to conventional adenocarcinoma, where positive CDX2 expression is more prevalent [34]. The gene discussed is CDX2; the disease is colon mucinous adenocarcinoma.