CDX2 and colorectal neoplasm: The CDX2 protein, while commonly associated with colorectal tumor cells, exhibits expression in various tumors of the digestive system, including duodenal (100%), gastric (71%), and pancreatic (30%) tumors, and may additionally be detected in neuroendocrine tumors and mucin-producing malignancies like bladder, ovarian, pulmonary, and biliary carcinomas [9,34,39].