Conversely, studies such as those performed by Çalık et al. and Issac et al., along with our own findings on the 43 analyzed cases of colon cancer, did not observe significant correlations between CDX2 expression and the histological subtypes of CRC, emphasizing the inconsistency and potential subtype-specificity of CDX2 expression across different studies [37,40]. Here, CDX2 is linked to colonic neoplasm.