MMP8 and periodontitis: Furthermore, Romanelli et al. [40], Mancini et al. [39], Gellibolian [42], and Overall et al. [37] have demonstrated by using different and independent collagenase activity assay and immunoassays that the major type of MMP-8 in progressive periodontitis lesions is aMMP-8 and not latent total proMMP-8.