CD274 and neoplasm: In conclusion, in this study, we determined that the immunohistochemical assessment of PD-L1 in tumor cells according to the TPS method of CRC was correlated with the location of tumors on the right side, the status of high microsatellite instability (MSI-H), weaker differentiation, higher pathological T stage, the existence of distant metastases, a higher TNM stage, and the existence of lymphatic as well as perineural invasion.