IL6 and bile duct papillary neoplasm: Other biochemical markers that have been used to distinguish between IPN vs. sterile necrosis include phospholipase A2 (PLA2) [64], cortisol-binding globulin (CBG) [65], soluble triggering receptor expressed on myeloid cells (sTREM1) [66], and interleukin-6 (IL-6) [67].