Intravenous administration of clarithromycin at therapeutic dosages has been shown to reduce serum concentration of TNF and reactive oxygen species in a murine model of sepsis caused by multi-sensitive E. coli, multidrug-resistant (MDR) P. aeruginosa, or pan-drug-resistant K. pneumoniae, and this was associated with survival improvement [8,9]. This evidence concerns the gene TNF and Sepsis.