AGT and heart failure: This suggests that the application of SLRPs may exert protection against cardiac damage, which is in line with several other observations proposing BGN- and DCN-derived beneficial effects against various cardiac pathologies, including I/R-induced cardiac damage [24,25,26], type 2 diabetes-induced cardiomyopathy [43], as well as angiotensin II-induced vascular abnormalities and heart failure [44,45].