While we characterized the expression of Gpr126 in different kidney diseases/disease models in detail, it remains unclear whether changes in Gpr126 expression are causal or drivers of kidney disease by inducing altered cell behavior and actively promoting disease in an attempt to protect the kidney, which might be inefficient due to missing receptor activation, or maybe even only an epiphenomenon. Here, ADGRG6 is linked to urogenital neoplasm.