To determine whether Gpr126 expression is altered during kidney disease, we performed RT-PCR analyses measuring the Gpr126 RNA levels in kidneys from animal models with mild (Ang II treatment, model of hypertensive nephropathy, mouse [24]) and severe kidney damage (I/R, model of AKI, rat [25]; UUO, model of interstitial fibrosis occurring in chronic renal failure, mouse [26]). This evidence concerns the gene ADGRG6 and chronic kidney disease.