SEMA3A and acute kidney injury: Based on a microarray-based analysis and a Western blot analysis, as well as a series of in vitro assays including the siRNA-mediated knockdown of Adgrg3 expression, the authors showed that Adgrg3 mediates its protective function via semaphorin 3A signaling and concluded that “Adgrg3 is an important mediator of AKI, and pharmacologic targeting of Gpr97-mediated Sema3A signaling at multiple levels may provide a novel approach for the treatment of AKI” [9].