ADGRG6 and focal segmental glomerulosclerosis: As the rodent model of podocyte depletion and human FSGS share a lot of common pathophysiological features, including podocyte loss followed by the induction of repair mechanisms and, subsequently, glomerular scarring [19,39], and the trend of increased Gpr126 expression in the glomeruli of patients with FSGS based on the NephroSeq data (Figure S2 and Data S1), this condition was selected to be studied further.