In a neonatal hypoxic-ischemic encephalopathy model, intraperitoneal injection of MT (15 mg/kg) into pups 1 h before hypoxia induction upregulated the expression of NLRX1, which downregulated mTOR expression and promoted ATG7 and Beclin-1 expression to promote mitophagy and inhibit apoptosis [46]. The gene discussed is BECN1; the disease is perinatal asphyxia.