While none of the 9 RDH8 variants are classified as pathogenic or likely pathogenic according to the American College of Medical Genetics and Genomics/Association for Molecular Pathology guidelines [66], for the 506 reported RDH12 variants, 112 have so far been reported as either pathogenic or likely pathogenic, with most cases being clinically classified as Leber Congenital Amaurosis 13 (LCA13). Here, RDH8 is linked to Leber congenital amaurosis 13.