RDH12 and Leber congenital amaurosis 13: While none of the 9 RDH8 variants are classified as pathogenic or likely pathogenic according to the American College of Medical Genetics and Genomics/Association for Molecular Pathology guidelines [66], for the 506 reported RDH12 variants, 112 have so far been reported as either pathogenic or likely pathogenic, with most cases being clinically classified as Leber Congenital Amaurosis 13 (LCA13).