AGTR1 and cardiac hypertrophy: Since Ang II is known to activate AT2R and its metabolite, Ang (1–7) activates MASR to produce antihypertrophic responses for limiting the development of cardiac hypertrophy induced through AT1R activation [102,104]; the net growth of myocardium due to Ang II is considered to be a balance between the effects of AT1R activation and AT2R as well as MASR activations.