For example, a depression in cardiac output and a decrease in blood pressure due to myocardial infarction, cardiomyopathies and inflammatory diseases stimulate the SNS and peripheral RAS for the release of catecholamines (norepinephrine from the sympathetic nerve endings and epinephrine from the adrenal medulla) and promote the release of renin from the kidney for the formation of Ang II, respectively. This evidence concerns the gene REN and myocardial infarction.