MDM2 and hydrops fetalis: Within the list of differentially upregulated genes (DEGs) induced by IR and known to be regulated by TP53, 10 out of 26 were shared between i-HF and HF, including MDM2 and CDKN1A (p21), as shown in a two-set Venn diagram (Figure 2b,d and Supplementary Figure S2a).