However, in i-HF lines, the SASP was much lower overall in response to H-RASV12-induced senescence, particularly for the secretion of GM-CSF, MIP-1b, MCP-3, CXCL9, PDGF, EGF, fractalkine, and TNFα (Figure 4b). The gene discussed is CX3CL1; the disease is hydrops fetalis.