The recent spatial transcriptomic analysis of human lung cancer patients indicates that spatially organized ‘immunity hubs’ consisting of stem-like IFNγ+ T cells in residence with myeloid cells in a CXCL10/11-CXCR3 dependent manner are associated with positive response to anti-PD-1 therapy [101]. The gene discussed is CXCR3; the disease is lung carcinoma.