In a desmoplastic intrahepatic cholangiocarcinoma (ICC) mouse model, cancer-associated fibroblasts (CAFs) recruited CD33+ MDSCs to the tumor and also mediated hyperactivation of 5LO metabolism in the MDSCs through CAF-derived IL-6 and IL-33 [330]. The gene discussed is IL6; the disease is intrahepatic cholangiocarcinoma.