NK cells expressing NKp46 can also interact with CALR, but NK cells are relatively rare in glioblastoma and typically are confined to the perivascular space—the zone of CXCL9/10/11/12 chemokine support, which would require a strategy to drive these cells deep into the TME alongside a strategy to prevent them from becoming immune suppressed. Here, CXCL9 is linked to glioblastoma.