SLC12A1 and idiopathic type 1 diabetes: In recent years, efforts to better characterize NKCC2 function and regulation have revealed that it is essential to elucidate the underlying mechanisms and respective protein networks governing NKCC2 expression at the molecular level to elucidate the pathophysiology of type 1 BS and explore new options to improve the available treatments for this salt-losing tubulopathy and salt-sensitive hypertension.