➢ATRA (40 μM) promoted autophagy in PLC/PRF/5 and HLE cells as demonstrated by,➢up-regulation of LC3-II and decrement of p62/SQSTM (Wang 2021) [50].➢up-regulation of ATG7 protein and ATG7 mRNA (Wang 2021) [50].➢The downregulation of ATG7 gene expression by siRNA enhanced 40 μM ATRA-induced cell death in hepatoma cells (Wang 2021) [50]. Here, ATG7 is linked to hepatocellular carcinoma.