IL10 and neoplasm: However, due to a highly immunosuppressive TME, caused by an immunosuppressive cytokine milieu/expression of the immunosuppressive molecules (for example, IL10, TGFß, PD-1L, TIM3-L, CTLA4-L, and LAC3-L) [81], it is more likely that T effector cells within a GBM tumor lesion are suppressed.