A recent study has revealed that aging-related fatty liver induced by the dysregulation of O-GlcNAcylation is closely associated with aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) and poly (ADP-ribose, PAR) polymerase 1 (PARP1) [101]. Here, AIMP2 is linked to fatty liver disease.