Exogenous molecules, such as curcumin [15], acetaminophen [53], and corosolic acid [171], and endogenous molecules, such as microRNAs [70,151,166], UAP1L1 [158], and SIX1 [19], affect certain liver diseases through the O-GlcNAc metabolic pathway. The gene discussed is UAP1L1; the disease is liver disorder.