The opposite is that under the hypoglycemia condition, glucagon promotes OGT phosphorylation by releasing Ca2+ to activate calcium/calmodulin-dependent kinase II (CaMKII); the phosphorylated OGT induces O-GlcNAcylation, which causes the phosphorylation of unc-51-like kinase 1 (ULK1) at different sites and subsequent liver autophagy [26]. Here, OGT is linked to Hypoglycemia.