For instance, in ribosomes, the O-GlcNAcylation of Ser122 promotes the stability of the receptor for activated C-kinase 1 (RACK1), which in turn enhances its interaction with protein kinase C βII (PKC βII) to result in eIF4E phosphorylation and activation, ultimately facilitating the translation of multiple oncogenes as well as cell proliferation, survival, migration, and invasion in HCC cells [167]. The gene discussed is EIF4E; the disease is hepatocellular carcinoma.