Increased HHLA2 expression correlated negatively with intratumoral CD3+ and CD8+ tumor-infiltrating lymphocyte (TIL) counts in ICC, while HHLA2-high specimens exhibited elevated CD4+ Foxp3+ scores, implying that HHLA2 could silence immunological responses during the disease [13]. The gene discussed is CD4; the disease is intrahepatic cholangiocarcinoma.