Increased HHLA2 expression correlated negatively with intratumoral CD3+ and CD8+ tumor-infiltrating lymphocyte (TIL) counts in ICC, while HHLA2-high specimens exhibited elevated CD4+ Foxp3+ scores, implying that HHLA2 could silence immunological responses during the disease [13]. This evidence concerns the gene HHLA2 and intrahepatic cholangiocarcinoma.