It also markedly decreased the secretion of eight cytokines including IFNγ, TNFα, IL13, IL9, IL10, IL17A, IL4, and IL22, indicating the suppressive role of HHLA2 on TCR-dependent T cell proliferation and cytokine production in NSCLC [20]. The gene discussed is HHLA2; the disease is non-small cell lung carcinoma.