ADGRD1 and viral infectious disease: G protein-coupled receptor 133 (GPR133) has so far not been implicated in viral infections, but it has been shown to play a role in the tumourigenesis of glioblastoma [29,30,31], while the dissociation of the N- and C-terminus of GPR133 leads to increased levels of cytosolic cyclic AMP [32,33,34,35].