To evaluate the mechanisms by which PA inhibits tumor growth in vivo, the expression of Bcl-xL, PERK, VEGF-R2, phospho-ACC, ATGL, phospho-42/44, and phos-S6 was examined by IHC, and serum VEGF production was determined by an ELISA assay in the endometrial tumors of Lkb1fl/flp53fl/fl mice. The gene discussed is KDR; the disease is endometrium neoplasm.