Our results showed that 250 μM PA significantly decreased the expression of phosphorylated AKT, S6, 4-EBP1, p38, and p42/44 in the Ishikawa and ECC-1 cells and inhibited the expression of phosphorylation of S6 and p42/44 in PA-treated tumor tissues. This evidence concerns the gene EIF4EBP1 and neoplasm.