Qian Guo et al. found that the thioredoxin-interacting protein (TXNIP) aggregated abnormally in the livers of NASH mice, and that the level of TXNIP protein was positively correlated with that of the CCAAT/enhancer-binding protein homologous protein (CHOP). The gene discussed is DDIT3; the disease is metabolic dysfunction-associated steatohepatitis.