PTEN and hepatocellular carcinoma: In the meantime, the authors also reported that NEDD4 overexpression enhanced the migration, invasion, and apoptosis of human hepatocellular carcinoma cells (Hep3B cell line) with downregulation of CFDP1, which means that CFDP1 is involved in HCC tumorigenesis and development via the NEDD4-mediated PTEN/PI3K/AKT pathway.