NEDD4 and colorectal carcinoma: MCM8 plays a role in regulating CHSY1 protein stability by affecting the NEDD4-mediated ubiquitination of chondroitin sulfate synthase 1 (CHSY1), which promotes CRC proliferation by mediating the nuclear factor-κB (NF-κB) and caspase-3/7 signaling pathways [92].