NEDD4 and gastric cancer: DONG LI et al. found that decitabine (DAC) promoted the cell invasion and metastasis of GC cell line MGC 803 by mediating the ubiquitination degradation of the cyclic nucleotide-Ras guanine nucleotide exchange factors (CNrasGEFs) through upregulation of the expression of NEDD4 but had no effect on the invasive properties of another cell line, SGC 7901.