Jianping Guo et al. concluded that copper activated protein kinase B (PK B) (also known as AKT) in a copper transporter protein (CTR1)-dependent manner and bound to phosphatidylinositol-dependent 3-phosphate kinase 1) to promote the activation of AKT in a phosphatidylinositol 3-kinase (PI3K)-dependent manner, thereby contributing to the development of cancer. This evidence concerns the gene AKT1 and cancer.