Xiaocheng Tang et al. revealed that intercellular adhesion molecule 2 (ICAM 2) was significantly downregulated in GC cells and tissues and could be used to evaluate prognoses, and that ICAM 2 promoted the ubiquitination degradation of radixin (RDX) in a NEDD4L-dependent manner to inhibit GC cell proliferation and migration [88]. Here, ICAM2 is linked to gastric cancer.