AKT1 and pachyonychia congenita: Jie Wang et al. found that LINC00941 competitively bound to membrane-associated protein A2 (ANXA 2) to reduce the binding of ANXA 2 to NEDD4L, thereby inhibiting the degradation of ANXA 2, enhancing the stability of ANXA 2, and subsequently activating FAK/AKT signaling to promote the proliferation and metastasis of PC cells.