NEDD4 and colorectal carcinoma: Recently, Ying-Nan Wang et al. cultured CRC cells with cholesterol-lowering agents and lipoprotein-free medium, and found that SR10 [84], a RAR-related orphan receptor α/γ (RORα/γ) agonist, could activate the transcription of NEDD4 by binding to the promoter of the NEDD4 gene, thus promoting the ubiquitylation and degradation of c-myc and inhibiting the proliferation and metastasis of CRC cells.