Hexu Han et al. found that NEDD4 binding protein 3 (N4BP3) was highly expressed in HCC, and the C-terminus of N4BP3 interacted with lysine acetyltransferase 2B (KAT2B) to regulate the distribution of the promoter of acetyl-histone H3 (Lys 27) (H3K27 ac) and increase the expression of the signal transducer and activator of transcription 3 (STAT3), thereby increasing the expression and secretion of vascular endothelial growth factor A (VEGFA) to promote angiogenesis in HCC. This evidence concerns the gene STAT3 and hepatocellular carcinoma.