Notably, Jarred P. Tanksley et al. investigated the expression of the NEDD4 family based on microarray analysis of 250 tumor samples from CRC patients at different stages, six adenoma samples, and 10 adjacent normal samples, and found that the most pronounced upregulation and downregulation was observed in NEDD4 and NEDD4L, respectively. Here, NEDD4L is linked to neoplasm.