Similarly, Sen Zhang and colleagues reported that the expression of N-myc downstream-regulated gene 1 (NDRG1) was downregulated in CRC tissues, and that NDRG1 could suppress the proliferation of colorectal tumors by inhibiting the NEDD4-mediated ubiquitination degradation of P21, suggesting that NDRG1 may be a potential anti-oncogene in CRC development. Here, NEDD4 is linked to colorectal carcinoma.