For example, NEDD4 is overexpressed in a number of cancers (e.g., breast, bladder, and colon cancer) [59,60,61,62], where it can perform its oncogenic or oncostatic function by inducing the ubiquitination of PTEN, Myc, Ras, and other substrates [63,64,65]. The gene discussed is NEDD4; the disease is cancer.