The NEDD4 gene, located on human chromosome 15q21.3, is commonly expressed in a variety of human organs and tissues (e.g., skin, liver, thyroid, kidney, and vascular endothelial cells) [40,55,56] and has been associated with the development of a variety of diseases, including cancer, cardiovascular diseases, metabolic diseases, neurological diseases, renal diseases, digestive diseases, etc. [48,55,57,58]. This evidence concerns the gene NEDD4 and digestive system disorder.