The results indicate that reduction of NEDD4L resulted in TXNIP accumulation in the liver due to impaired ubiquitination degradation, suggesting that TXNIP knockdown can inhibit the expression of CHOP and its downstream apoptotic pathway, therefore exerting an improving effect on NASH by reducing apoptosis, inflammation, and fibrosis in the liver [105]. This evidence concerns the gene DDIT3 and metabolic dysfunction-associated steatohepatitis.