It was also shown that NEDD4 gene knockdown significantly reduced the migratory and invasive ability of GC cells, suggesting that NEDD 4 may be a biomarker for determining the prognosis of gastric cardia adenocarcinoma (GCA) among GC types, and that NEDD4 may be a new target for antimetastatic GC therapy [122]. Here, NEDD4 is linked to gastric cardia adenocarcinoma.