Surprisingly, another study revealed that the expression of NEDD4L was downregulated in HCC tissues compared with paraneoplastic tissues, and by analyzing the relationship between NEDD4L and the clinicopathological features of HCC patients, NEDD4L was shown to exert a tumor suppressor effect in HCC by triggering MAPK/ERK-mediated apoptosis. This evidence concerns the gene NEDD4L and hepatocellular carcinoma.