A study showed that NEDD4 targets the transcription factor YY1 (YY1) for its ubiquitination and degradation, resulting in a decrease in the ratio of full-length LEF 1 (FL-LEF 1)/dominant-negative LEF 1 (DN-LEF 1) transcripts, which then inhibits the activation of WNT signaling and the growth of intestinal tumors in Apc+/min mice [64]. The gene discussed is YY1; the disease is intestinal neoplasm.