Methylation of KIF5C (kinesin family member 5C) is a promising biomarker for ulcerative colitis ulcerative-associated neoplasia [37], and methylation of the secreted frizzled-related protein 2 gene (SFRP2) is a promising noninvasive biomarker for diagnosing colorectal cancer through fecal sample analysis [38]. This evidence concerns the gene SFRP2 and ulcerative colitis.