High-grade metastatic breast cancers with a poor prognosis exhibit epigenetic silencing of CREB3L1 (cAMP-responsive element-binding protein 3-like protein 1) through DNA methylation, a phenomenon prevalent particularly in triple-negative breast cancers [42], and member 26B of the kinesin family (KIF26B) is widely recognized as an oncogene in breast, gastric, colorectal and hepatocellular cancers. The gene discussed is KIF26B; the disease is hepatocellular carcinoma.