With low expression in metastatic bladder cancer tissues, RBMX can competitively bind to the RGG motif of hnRNPA1 and block it from combining with the lateral intron of PKM mRNA exon 9, leading to high expression of PKM1 and weakening the malignancy and progression of tumors [39]. The gene discussed is HNRNPA1; the disease is urinary bladder cancer.