Additionally, Astragaloside IV, Xiang Lin pills, berberine, and fluoxetine can inhibit the TLR4/MyD88/NF-κB signals, thereby exerting the effects of acute myocardial infarction, colitis, and ischemia-reperfusion injury, and relieve postoperative cognitive dysfunction and neuroinflammation in elderly mice [67,68,69,70,71,72,73,74,75,76,77,78,79,80]. This evidence concerns the gene TLR4 and colitis.