Meanwhile, in a preclinical study of colorectal cancer, researchers found that silencing MyD88 in SW480 (human colon adenocarcinoma cells) and HCT116 (human colon cancer cells) interferes with the MyD88/NF-κB/AP-1 signaling pathway and significantly inhibits cancer cell growth and invasion. The gene discussed is NFKB1; the disease is colorectal cancer.