Simultaneously, Guo et al. identified the core genes involved in the regulation of the glioma immune microenvironment with the help of bioinformatics technology and found that MyD88 could cause disorders in tumor-infiltrating immune cells, especially promoting the transformation of macrophages into the M2 type [48], thereby providing good prognostic value for patients with glioma. This evidence concerns the gene MYD88 and central nervous system cancer.