Additionally, researchers have found that a novel extracellular vesicle-like ginseng derived nanoparticle could induce the polarization of M1-like macrophages in mice with B16F10 melanoma through the TLR4/MyD88 signaling pathway and enhance the production of total reactive oxygen species to induce melanoma cell apoptosis [57]. This evidence concerns the gene MYD88 and melanoma.