The epidermal growth factor receptor (EGFR) can recruit mitogen-activated protein kinase kinase kinase 3 (MEKK3) in a tumor necrosis factor receptor (TNF-R)-associated factor 4 (TRAF4)-dependent manner, which activates ERK5 and supports the proliferation of non-small-cell lung cancer cells [50]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.