Erazo et al. discovered that Cdc37 overexpression promotes Hsp90’s dissociation from the ERK5-Cdc37 complex and facilitates the nuclear translocation of non-phosphorylated yet transcriptionally active ERK5, suggesting that ERK5 may promote tumor progression without specific activating enzymes in some cancer types [22]. This evidence concerns the gene MAPK7 and neoplasm.