Bayo et al. revealed that higher levels of BRD9, HAT1A, the KMTs (SUV39H2, SMYD1, NSD2, and KMT5A), and the KDMs (LSD1/KDM1A, LSD2/KDM1B, KDM3A, KDM5C, and RIOX2) were associated with poor prognosis among patients with HCC. The gene discussed is KDM1B; the disease is hepatocellular carcinoma.