Many psoriasis risk genes are involved in this pathway; TNFAIP3, NF-ΚBIZ and TNIP1 are involved in pathway regulation, with NF-ΚBIA inhibiting the pathway, RELA coding for an NF-κB subunit and TRAF3IP2 coding for ACT1 (Table 1). Here, TRAF3IP2 is linked to psoriasis.