We have reported that among severe asthma cases with high FeNO (>27 ppb) and a low blood eosinophil count (<265 cells/μL), with the treatment including an anti-IL-5/IL-5R Ab, almost half of the cases demonstrated sputum eosinophilia (>2.7%) [25]. This evidence concerns the gene IL5 and Increased total eosinophil count.