For example, EV71 (2Apro) has been found to upregulate the expression and secretion of LDL-receptor-related protein-associated protein 1 (LRPAP1), and the N-terminus of secreted LRPAP1 can bind with the extracellular domain of IFNAR1, triggering the receptor’s ubiquitination and degradation and promoting virus infection both in vitro and in vivo [14]. This evidence concerns the gene LRPAP1 and viral infectious disease.