Pathological reactive astrocytes cause inflammation and neuropathies and, together with microglia and neurons, interact in spinal cord dorsal horn pain signaling [197], and there is growing evidence that astrocytic BDNF has an important role in nociception [152], chiefly in neuropathic pain, primarily because of the activation of trkB.T1 [198] (Figure 3C). Here, BDNF is linked to neuropathy.