SEMA4A and myocardial ischemia: Regarding the SEMA4A, which is involved in cell activation, immune response, T-cell differentiation, and lymphocyte differentiation according to BP, an in vivo cardiac ischemia–reperfusion mouse model showed SEMA4A to be highly expressed in macrophages recruited at the injured area, and it was suggested to exert a role activating angiogenesis and inflammation [73].