Using immortalized Caco-2 cells, which are derived from human colorectal adenocarcinoma as a model, caspase-5 was reported to contribute, along with sorting nexin 10 (SNX10) and the PIKFYVE kinase, to the release of LPS from internalized bacterial outer membrane vesicles into the cytosol. This evidence concerns the gene SNX10 and colorectal adenocarcinoma.