Additionally, insulin and IGF-1, thanks to the IRS-1-PKB -FoX01 pathway, growth factors via the Ras-ERK-NFATc4 pathway, IL6 and IL-8 via the STAT3-cFOS-FoX01 axis, and FFAs induce an important inhibition of adiponectin gene expression, which is vital in prostate cancer prevention and handling due to its related antiangiogenic activity, and it is also inhibited via the AMPK-TSC pathway, resulting in the prevention of mTOR activation [98]. Here, IRS1 is linked to Familial prostate cancer.