BAP1 and hereditary clear cell renal cell carcinoma: Thus, among the BAP1-mutant families affected by the BAP1 tumor predisposition syndrome (BAP1-TPDS), those individuals who have inherited a BAP1 mutant allele may develop one or more malignancies during their lifetime, mostly uveal melanoma, malignant mesothelioma, cutaneous melanoma, renal cell carcinoma, and basal cell carcinoma [38].