For example, 100 nM of 1α,25(OH)2D3 was shown to inhibit cellular proliferation in endometrial carcinoma cells by targeting and modulating actin cytoskeleton organization via the ras-related C3 botulinum toxin substrate 1 (RAC1)/p21 protein-activated kinase 1 (PAK1) signaling pathway [21,22]. The gene discussed is RAC1; the disease is endometrial carcinoma.