RHOA and neoplasm: Ingenuity Pathway Enrichment Analysis of our top canonical pathways revealed significant enrichment and predicted repression of the following pathways: actin cytoskeleton signaling, regulation of Epithelial–Mesenchymal Transitioning (EMT) growth factors pathway, tumor microenvironment pathway, telomerase signaling, RhoA (Ras homology family member A) signaling, and actin nucleation via ARP-WASP (Actin-related Protein Wiskott–Aldrich Syndrome Protein) complex and regulation of actin-based motility by Rho (Figure 1A).