In terms of the recent NB classification, in which NB cells were classified into either the ADRN type, associated with a sympathetic neuronal cell state, or the MES type, associated with an undifferentiated neural crest-like cell state, CRMP1, DBH, DDC, GAP43, ISL1, PHOX2B, and TH genes were all classified into ADRN-type genes [29,30,31]. This evidence concerns the gene ISL1 and neuroblastoma.